In another report, the levels of plasma membrane-associated PHB1 and migration-inducting gene-7 (MIG-7) were positively correlated with advanced stages of cancer in human lung tissues.45 These results suggest that Akt phosphorylates PHB1 at Thr-258, and phosphorylation of PHB1 plays an important role in the development and progression of different types of human lung cancers. This evidence concerns the gene AKT1 and cancer.