However, pancreatic islets from the female m-Mito-Ob mice fed a high-fat diet and male m-Mito-Ob mice fed a low-fat diet were negative for CD8 and F4/80.81 These experimental findings indicate that PHB1 may play a role in immune checkpoints and that Tyr-114-mutant PHB1 may function as a genetic susceptibility factor in adult-onset T1D. Here, PHB1 is linked to type 1 diabetes mellitus.