In this context, it is important to note that Thr-258 in PHB1 and Ser-259 in Raf-1 are located in the Akt consensus motif R-x-R-x-x-S⁄T.46 It is therefore conceivable that Thr-258 phosphorylation in PHB1 may compete with the Ser-259 phosphorylation of Raf-1 thereby reducing the phosphorylation of Raf-1 and facilitating its activation to promote cancer cell proliferation. Here, AKT1 is linked to cancer.