Consistent with previous findings, a recent report has demonstrated that Akt phosphorylates PHB1 at Thr-258 in human bladder cancer cells.44 Phosphorylation of PHB1 by Akt promotes its mitochondrial localization and leads to the proliferation of bladder cancer cells.44 Furthermore, substitution of Thr-258 by alanine induced cell death in bladder cancer cells.44 These results demonstrate that PHB1 is an important regulator during bladder cell tumorigenesis and that the phosphorylation of PHB1 at Thre-258 plays a key role in this process. This evidence concerns the gene PHB1 and urinary bladder cancer.