The other class of TLRs localize to the cytoplasm, and include TLR3, 7, 8 and 9, which mainly recognize the nucleic acid composition of the pathogen.5 TLRs are mainly expressed on innate immune cells, such as dendritic cells (DCs), mast cells, macrophages, neutrophils, endothelial cells and natural killer (NK) cells.6 In recent years, numerous studies have shown that TLRs are also expressed in tumor cells and cells in the tumor microenvironment of various cancers. The gene discussed is TLR3; the disease is neoplasm.