However, they also observed that TLR4 expression declined during the progression of cervical cancer, and this downregulation of TLR4 appeared to be associated with the expression of P16INK4A, which is a crucial marker of HPV integration into host cells.74 These data may offer further insight regarding the association of HPV infection and TLR signaling during the development of cervical cancer. This evidence concerns the gene CDKN2A and cervical cancer.