TLR4 and cervical cancer: However, they also observed that TLR4 expression declined during the progression of cervical cancer, and this downregulation of TLR4 appeared to be associated with the expression of P16INK4A, which is a crucial marker of HPV integration into host cells.74 These data may offer further insight regarding the association of HPV infection and TLR signaling during the development of cervical cancer.