TLR1 mRNA was decreased in cervical squamous cell carcinoma, yet the expression levels of TLR1, 2, 5, 6 and 9 were increased in parallel with the increase in the level of cervical lesions.39 This result suggests that there are specific temporal and spatial regulations of TLR expression in the different stages of lesion tissue and of cervical cancer development. This evidence concerns the gene TLR1 and cervical squamous cell carcinoma.