When iNOS activity was inhibited, the growth of tumor cells was also inhibited.48 Xiao et al.49 detected the mRNA and protein expression of TLR/iNOS pathway transduction molecules including TLR4, NF-κBp65 and iNOS in different cervical cell lines, and they found TLR4/iNOS pathway is highly expressed in cervical cancer with hrHPV infection which may be resulted in cervical tumorigenesis. The gene discussed is TLR4; the disease is neoplasm.