We first examined BTK, a tyrosine kinase critical in mediating BCR signaling in CLL cells.30 As shown in Figure 5a(i), we observed a significant reduction in phosphorylated BTK at Y223 in JVM-3 cells after only 4 h treatment with CNL, while total BTK remained unchanged. The gene discussed is BTK; the disease is B-cell chronic lymphocytic leukemia.