Furthermore, treatment with U0126, a MEK inhibitor (proof of MEK inhibition shown in Figure 5b(ii)), reduced p-STAT3-S727 and p-STAT3-Y705 in both JVM-3 cells (Figure 5b(iii)) and CLL patient cells (Figure 5b(iv)). Here, MAP2K7 is linked to B-cell chronic lymphocytic leukemia.