They found a PFKFB3 inhibitor, PFK-158, could decrease tumor-infiltrating Th17 cells and myeloid-derived suppressor cells, and increase tumor-infiltrating CD4+ and CD8+ T cells in the tumors of B16-F10 melanoma-bearing mice.111–113 However, the functions of different immune cells are different and complicated. The gene discussed is CD8A; the disease is neoplasm.