PFKFB3 and melanoma: The normalized vessels might also resist shedding of cancer cells from the primary tumor, potentially reducing tumor metastasis.102,103 A recent study found that inhibition of PFKFB3 in melanoma tumor endothelial cells (TECs) induces tumor vessel normalization, thus reducing cancer cell invasion, intravasation and dissemination, and contributing to increased response to chemotherapy.104 This effect is probably achieved by reducing VE-cadherin endocytosis and inflammation in ECs and making pericytes more quiescent and adhesive under reduced glycolysis.