The N-terminal domain is responsible for the synthesis of F2,6P2 from F6P and ATP (Figure 1b).14,16,17 The PFKFB3 protein is ubiquitously expressed, with especially high levels in proliferating tissues, transformed cells, solid tumors and leukemia cells.18 PFKFB3 expression could be upregulated in response to mitogenic, inflammatory and hypoxia stimuli and during the DNA synthesis phase of the cell cycle.18 Considering its significance in cancer metabolism, further explanation of the function of PFKFB3 in diverse cancers is necessary. This evidence concerns the gene PFKFB3 and cancer.