This finding indicates the significance of time-based PFKFB3 inhibition in cancer treatment.29 Growth factors, such as insulin,30 pro-inflammatory molecules such as interleukin 6 (IL-6),31 lipopolysaccharide (LPS) and adenosine32 or different stress stimuli (NaCl, H2O2, UV radiation or anisomycin)33, increase pfkfb3 gene expression levels. The gene discussed is IL6; the disease is cancer.