AKT1 and glioblastoma: 123 In a phase II trial combining high-dose Tamoxifen and radiotherapy, it was found that this molecule did not increase survival of patients.124 Worryingly, it was reported that high-dose tamoxifen treatment was linked with multifocal glioblastoma recurrence which mainly occurred in patients who responded to the Tamoxifen treatment.125 Enzastaurin is an inhibitor of the PKCβ and PI3K/AKT pathways that has been tested in phase I and phase II clinical trials.