PDGFRA and glioblastoma: This observation pinpoints to the importance of PDGF in GBM pathology.33,34 Data analyses from TCGA research network revealed amplification of platelet-derived growth factor receptor alpha (PDGFRα) in 10–13% of the cases studied.9,10 PDGFRα is the second most frequently amplified RTK in GBM behind EGFR.