PX-866 (Sonolisib) is an irreversible PI3K inhibiting drug that has been shown to inhibit angiogenesis and invasion of GBM cells in vitro. Although the drug did not induce apoptosis of GBM cells, it did cause cell cycle arrest.108 This drug was tested in a phase II trial for recurrent glioblastoma and was well tolerated but 73% of patients treated had disease progression.109 Other inhibitors such as XL765 (SAR245409) and GDC-0084, dual PI3K/mTOR inhibitors, have anti-GBM effects in vitro and in vivo but their efficacy in clinical trials must be tested and presented.110,111. Here, MTOR is linked to glioblastoma.