AP12009 (Trabedersen) is a TGF-β2-specific antisense oligonucleotide, that when delivered using convection enhanced delivery (CED) resulted in a longer median overall survival (in phase I/II trial).147 SB-431542, LY2109761 and LY364947 (HTS466284) are inhibitors of the TGF-βR1 tyrosine kinase that have been tested in the GBM setting. The gene discussed is TGFB2; the disease is glioblastoma.