HGF and glioblastoma: In phase II trial Aflibercept appeared to have little activity for recurrent GBM patients with only 7.7% of patients experiencing progression free survival after 6 months.84 Rilotumumab (AMG102) is an anti-HGF monoclonal antibody that binds HGF and prevents its binding to the HGFR/c-MET, and consequent activation of downstream targets.