ErbB2/HER-2 mutation was also detected in 8–41% of GBM cases.9,26 A truncated mutant EGFR variant III (EGFRvIII) is frequently expressed in glioblastoma multiforme and is constitutively activated in a ligand independent manner, resulting in cell proliferation and survival. This evidence concerns the gene ERBB2 and glioblastoma.