For that the early detection program and newborn screenings must be established in order to avoid further consequences.4 Though restoring SMN expression rescues early lethality in SMA mouse model, there will be an adequate requirement to find out alternative mechanisms and molecular pathways that provide additional protection to the motor neurons, evade muscle degeneration and also to find potential therapeutic targets (Figure 1). The gene discussed is SMN1; the disease is proximal spinal muscular atrophy.