For instance, increased ROS levels can activate NF-κB signaling and induce EMT-related morphological changes, whereas administration of the antioxidant N-acetylcysteine (NAC) or the NF-κB-specific inhibitor DHMEQ significantly reverses ROS-induced EMT.57,58,59 Furthermore, ROS confer pancreatic cancer cells with invasive ability by activating NF-κB signaling. The gene discussed is NFKB1; the disease is pancreatic neoplasm.