PTK2 and neoplasm: In addition, previous reports have revealed that the FAK-p130Cas complex can mediate matrix degradation by recruiting MT1-MMP to focal adhesions.95 Furthermore, FAK activation confers tumor cells with anoikis resistance by interacting with Mdm2 and promoting the subsequent proteasomal degradation of p53.96 Recent studies have suggested that ROS can regulate cell mobility by modulating FAK activation.