For instance, miR-212 has been reported to target manganese superoxide dismutase (MnSOD) to inhibit the invasion and pulmonary metastasis of colorectal cancer cells.170 Peroxiredoxin 1 (Prx1), another important antioxidant enzyme, has been demonstrated to affect nicotine-induced EMT in oral squamous cell carcinoma (OSCC). This evidence concerns the gene PRDX1 and colorectal cancer.