Further studies have shown that ZEB1 silencing enhanced the therapeutic effect of erlotinib in resistant cancer cells.121 Moreover, oxaliplatin-resistant colorectal cancer cells exhibit a similar phenotype to EMT.122 Consistent with these observations, suppression of EMT enhanced the sensitivity of pancreatic cancer cells to gemcitabine.123 5-Fluorouracil is a first-line therapeutic agent for various types of cancer. This evidence concerns the gene ZEB1 and cancer.