CDH17 and neoplasm: Furthermore, Src also disrupts tumor cell adhesion by cooperating with MAPK and ROCK to stimulate the peripheral accumulation of phospho-myosin, thus maintaining the mesenchymal phenotype of tumor cells.26,100 In addition, Src has been reported to phosphorylate cadherin adhesion components (such as p120-catenin) to decrease cell–cell adhesion.101 The activity of Src is dependent on the phosphorylation status of two regulatory tyrosine residues: Tyr416 and Tyr527.