One of the effector proteins is IncE, which specifically interacts with SNX5/6 via their PX domain.27 SNX5/6 and other retromer components restrict Chlamydia trachomatis infection since their depletion leads to enhanced infection through mechanisms that are currently unclear.27 Overexpression of IncE in mammalian cells inhibits retromer- and SNX5/6-mediated endosomal trafficking.27 Thus, IncE functions to prohibit the inhibition effect exerted by the host retromer components. Here, SNX5 is linked to infection.