PPARG and Insulin resistance: Specifically, it has been shown in mice that chronic AT2R activation using C21 causes an increase of white adipocyte differentiation and PPARγ expression, and a decrease in adiposity, adipose tissue inflammation and insulin resistance,20,21,47 while knockout of AT2R does the opposite.55,56 And resting metabolic rate, detected by direct calorimetry method, is significantly decreased in AT2R knockout mice.57