Previous reports indicated that the CIP2A gene is expressed at high levels in cancer cells from the B lymphocyte and myeloid lineages.14,28,29 Li et al.29 used immunohistochemistry and QPCR to confirm that CIP2A is overexpressed in BM cells from patients with a group of high-risk myelodysplastic syndromes and might play a role in the proliferation of blasts in the myelodysplastic syndromes BM and in disease progression in at least some cases. This evidence concerns the gene CIP2A and cancer.