Consistently, a SEC62 knockdown markedly reduced the migration and invasion potential of prostate cancer cells90 as well as the migration of NSCLC cells,90 thyroid cancer cells90 and cervical cancer cells,91 whereas SEC62 overexpression stimulated the migration of cervical cancer cells91 and even human embryonic kidney cells.90 The latter is particularly telling since it provided a direct link between Sec62 and cell migration. Here, SEC62 is linked to Familial prostate cancer.