SEC62 and esophageal cancer: This hypothesis is further substantiated by the fact that the SEC62-encoding chromosomal region 3q26 is amplified in numerous human cancer entities including cervical cancer,95,96 non-small-cell lung cancer,97 esophageal cancer,98 ovarian cancer,99 and head and neck cancer.100,101 Hagerstrand et al.102 screened 3131 tumor samples from 26 different tumor entities for somatic copy-number alterations and found the SEC62-encoding region 3q26 to be amplified in 22% of cases.