Comparably, the Sec62 protein levels in NSCLC as well as head and neck squamous cell carcinomas tissue samples significantly correlated with a shorter overall survival.68,92 For NSCLC patients, an additional correlation of high Sec62 levels with a dedifferentiation of the tumors and the occurrence of lymph node metastases was found,90 again pointing to a potential function of Sec62 in tumor metastasis. The gene discussed is SEC62; the disease is head and neck squamous cell carcinoma.