SEC62 and cancer: Of note, neither SEC62 silencing nor SEC62 overexpression markedly affected cell proliferation in these studies.89–91 However, other studies reported an impairment of cell proliferation in Sec62-depleted cell lines harboring a 3q26 amplification102 as well as in Sec62-depleted HeLa cells.32 Though all of these studies indicate a crucial role of SEC62 in cancer cell migration and invasion—molecular processes that are essential for tumor metastasis—it is not yet clear how this function of Sec62 is mediated on the molecular level.