SIRT3 and neoplasm: PDC is often inactivated in tumor cells and is a possible cause of the Warburg effect.15 Conversely, PDC activation could be a possible strategy to prevent or treat cancer.16 PDC activity is reportedly regulated by SIRT3-mediated acetylation.17 Furthermore, SIRT3 is also involved in the regulation of oxidative phosphorylation through the regulation of complex I of the electron transfer chain.