In this study, we focused on the investigation of Lyn’s role in AMs, because the mortality of PAO1-infected mice is highly AM-dependent.34 As one of the primary inflammatory cytokine source in the lung and BALF,35 excessive activation of AMs increases inflammation and stimulates immune system,45 leading to programmed cell death and mice mortality.45,47 Previous studies showed that both Lyn and pro-inflammatory cytokine IL-6 were involved in several autoimmune diseases. Here, LYN is linked to autoimmune disease.