PAO1 infection of macrophages induces expression of transcription factor NF-κB, promotes its nucleic translocation and activates its downstream cytokine gene transcription.44 It has previously been reported that SHIP-1 positively regulates NF-κB-dependent gene transcription in macrophage RAW264.7 in response to LPS stimulation.45 Therefore, we asked whether SHIP-1 and Lyn influenced gene expression driven by NF-κB in AMs in response to PAO1 infection. This evidence concerns the gene NFKB1 and infection.