For example, Lyn directly phosphorylates STAT3 to impact proliferation, differentiation or growth arrest in B cells.49 In our study, inhibition of Lyn and Ezrin, respectively, resulted in a decreased cell viability after PAO1 infection (Figure 2j), indicating that this complex has a critical role in host defense against P. aeruginosa. The gene discussed is STAT3; the disease is infection.