C3 and age-related macular degeneration: According to our lifetime risk model, the relative score values of 8 variables: CFH (rs412852), BMI, VEGFA (rs3025000), SMOKING, C3 (rs2230199), ARMS2 (rs10490924), HTRA1 (rs11200638) and APOE (rs7412) were close to or >50, what proved their high contribution to the AMD development and reliability of the prediction model.