The following 15 loci with 25 common SNPs and established association with AMD were included in the present study to develop class prediction algorithms for lifetime risk assessment and disease progression: ABCA1 (rs1883025); APOE (rs429358, rs7412); ARMS2 (rs10490924); C3 (rs2230199); CCDC109B (rs17440077); CETP (rs3764261); CFB (rs4151669, rs522162); CFH (rs1048663, rs1061170, rs10737680, rs1329428, rs2274700, rs3766405, rs412852); CFI (rs10033900); COL8A1 (rs13095226); HTRA1 (rs11200638); LIPC (rs493258, rs10468017); LPL (rs12678919); TIMP3 (rs9621532) and VEGFA (rs3025000, rs943080). The gene discussed is COL8A1; the disease is age-related macular degeneration.