TF and Parkinson disease: Reduced Tf has previously been reported in PD serum,17 where it has increased sialyation.23 Tf haplotype variability modifies the risk for PD.24,25 Further, Tf is mis-compartmentalized in the mitochondria of SN neurons in PD that could contribute to decreased Tf and the brain.26 The loss of Tf could restrict normal iron flux in the brain, as Tf is the major transporter of iron between cells.