XPO1 and cancer: For instance, epidermal growth factor receptor inhibitors reduce cancer proliferation, CDK inhibitors stop cell cycle and BH3 mimetics promote cell death.130–132 In response to such single-target therapy, cancer cells may reduce their reliance on a particular protein and develop more dependence on another.75,133 Importantly, CRM1-mediated nuclear export is a significant contributing factor in the development of drug resistance.70,134,135 As CRM1 inhibition could downregulate 9 out of 10 cancer features simultaneously, it probably would be more effective than targeting a single pathway.