MYC and hepatocellular carcinoma: Consistent with its oncogenic role, c-Myc also represses transcriptional activity of tumor suppressive miRNAs such as mir-15a, miR-26, miR-29, mir-30 and let-7 families.29 Ghoshal’s group found the reciprocal regulation of c-Myc and tumor suppressor miR-122 in hepatocellular cancer.