DICER1 and neoplasm: Regarding to Dicer dysregulation, it was observed that Dicer1 impairment in colorectal cancer (CRC) cells induces the acquisition of a greater capacity for tumor initiation and metastasis.56 Moreover, high Dicer and Drosha mRNA levels in ovarian cancer are associated with increased median survival,57 and reversely, decreased Dicer expression significantly correlates with reduced patient survival.58,59 The positive correlation between lower Dicer mRNA levels and reduced let-7 expression with unfavorable postoperative survival was also discovered by Karube et al.60 in lung cancer patients.