It targets PTEN to activate the downstream Akt/ERK signaling pathways, leading to high expression of HIF1α and VEGF.117 In contrast, miR-20b and miR-519c negatively regulate angiogenesis by targeting VEGF and/or HIF1α.118,119 Besides regulating HIF1α, miR-107 was able to inhibit the expression of HIF1β, so downregulation of miR-107 promotes tumor angiogenesis under hypoxic conditions.120. This evidence concerns the gene HIF1A and neoplasm.