Similar to p27Kip1, p21CIP1 and p16INK4a are also regulated by miRNAs such as miR-663, miR-302 family and miR-24.76,77 miR-663 was found to be upregulated in nasopharyngeal carcinoma, and acts as oncogene to promote the cellular G1/S transition in vitro and in vivo by directly targeting p21CIP1. This evidence concerns the gene CDKN1A and nasopharyngeal carcinoma.