JAG1 and infection: The commonly used inbred mouse strains C57BL/6 (H-2b) and BALB/c (H-2d) are known to respond differently to Ags and infections with distinct polarisations of T-cell responses and differing protection efficiencies.27,28 We have found differences between these strains in the adjuvant-free responses to Clec9A-targeted Ags.19 To check if our findings with putative vaccine Ags would apply across these different mouse strains, a direct side-by-side comparison of the responses to the M2e and SP70 constructs was made (Fig. 2a, b).