The in vivo efficacy of antibodies against single antigens, such as CSP, can also be tested in standard mice using transgenic rodent malaria parasites where the endogenous antigen of interest has been replaced by the Pf ortholog.16–18 However, creation of these parasites is complex and the Pf protein must fully complement the cognate rodent malaria parasite protein to yield a viable parasite. This evidence concerns the gene DNAJC5 and malaria.