Subcapsular sinus macrophages (SSM) promote innate IFNγ responses to infections, orchestrating both NK and CD8+ T cells in this response.26, 27 To investigate whether SSM support early IFNγ production by AS01, we depleted SSM by i.m. administration of clodronate liposomes 6 days before the injection of AS01. Here, CD8A is linked to infection.