This antibody binds to an HIV gp120 core glycoprotein stabilized in the CD4-bound conformation and lacking the variable (V) loops 1 to 3.90 Antibody 3BNC117 blocked infection and suppressed viremia in macaques infected with the R5 tropic simian-human immunodeficiency virus (SHIV)-AD8, which emulates many of the pathogenic and immunogenic properties of HIV-1 during infections of rhesus macaques.91 In Phase 1 trial, 3BNC117 is safe and effective in reducing HIV-1 viremia.92 In a Phase 2a trial, 3BNC117 suppresses viral rebound in humans during treatment interruption. Here, CD4 is linked to infection.