VRC01 is a broadly neutralizing HIV-1 mAb isolated from the B cells of an HIV-infected patient.40, 83 It is directed against the HIV-1 CD4-binding site and is capable of potently neutralizing diverse HIV-1 strains.84 A Phase 1 study showed that the antibody was safe and demonstrated expected half-life and pharmacokinetics for a human IgG.85 In two open-label trials of the safety, side-effect profile, pharmacokinetic properties, the antiviral activity of VRC01 was tested in persons with HIV infection who were undergoing ART (antiretroviral therapy) interruption. This evidence concerns the gene CD4 and HIV infectious disease.