To investigate whether KAS2-A1-specific T cells or B cells mediate protection in the mouse periodontitis model, donor mice (Ly5.1 C57Bl6 congenic mice) were immunised with KAS2-A1 chimera or ovalbumin (antigen control) and IgG1 and IgG2 expressing B cells and CD4+ T cells harvested and adoptively transferred into recipient mice (Ly5.2 C57Bl6 congenic mice). This evidence concerns the gene CD4 and periodontitis.