Mechanisms of ZIKV-induced disease and immunity are poorly defined, and the protective versus the hypothetical pathogenic nature of the immune response to ZIKV infection is as yet unclear.17 Most strains of mice are resistant to ZIKV infection, however, mice lacking IFN-α/β receptor (IFNAR−/−) were found to be susceptible to infection and disease with most succumbing within 6–7 days post challenge.18 The ability of the consensus ZIKV-prME plasmid vaccine to induce cellular and humoral immune responses in this mouse strain was investigated. Here, IFNAR1 is linked to infection.