Indeed, a pioneering study by Glenn et al. documented in mice that transcutaneous immunisation with cholera toxin induces IgA Abs in the lungs and protection against a nasal challenge with cholera.6 Moreover, we have previously reported in humans that TC delivery of the live-attenuated measles vaccine ROUVAX using a patch generates a transient salivary IgA Ab response,7 supporting the notion that skin might be an inductive site for mucosal Ab responses in humans. Here, CD79A is linked to vibrio infectious disease.