TTN variants seem to explain many cases of a rare hereditary condition previously linked only to mutations in the unrelated gene PTEN. Charis Eng and team from the Cleveland Clinic, Ohio, USA, sequenced the protein-coding DNA from 35 patients with Bannayan-Riley-Ruvalcaba syndrome (BRRS), a disease characterized by large head size, tumors and other overgrowth problems. Here, PTEN is linked to Bannayan-Riley-Ruvalcaba syndrome.