The functional consequences of TTN variants have been extensively evaluated in the context of dilated cardiomyopathy (DCM).25–29 In this context, one study reported the association of a TTN truncating variant with decreased growth factor signaling pathway readouts, such as diminished phosphorylation of MAPK and AKT,28 which are pertinently downstream of PTEN signaling. This evidence concerns the gene TTN and dilated cardiomyopathy.