SPECC1 and breast cancer: We analyzed the expression of all of the detectable abundant circRNAs (n = 252) in whole transcriptome RNA-Seq data from eight BC cell lines (Nhutert, HCV29, HT1197, RT4, J82, HT-1376, T24, and UMUC3).29 Consistent with the expression profiles between risk classes, most circRNAs (216/252) were expressed at higher levels in the non-malignant BC cell lines compared to the metastatic BC cell lines, e.g., a circRNA overlapping the SPECC1 gene, circCDYL, and circHIPK3 (Fig. 4e).