KRAS and cancer: Genomic mutational profiling of CTCs provides pertinent information for personalized therapy.23 Targeted next-generation sequencing (NGS) allows rapid detection of a variety of mutations of a gene panel on single platforms (such as Ion Torrent and MiSeq).24,25 Targeted NGS is especially useful to guide treatment when focusing on a drug actionable gene panel, with a fast turnaround time and a low cost, such as looking for mutations of KRAS, EGFR, or ALK/ROS1 rearrangements to guide the selection of cetuximab, erlotinib/Gefitinib, or crizotinib for cancer patients,26,27 respectively.