BRCA1 and cancer: Cases with FA nonsense mutations were only enriched in the fourth signature (Fig. 4c), a somatic signature similar to the BRCA1/2-deficiency signature from a pan-cancer analysis (signature 3 in the referenced publication).48 Enrichment of this somatic mutation signature in bladder cancer cases with nonsense FA variants suggests that these FA nonsense variants, whether somatic or germline, affect the bladder cancer somatic mutation landscape.