One of the discordant variants, rs10797431 at the MMEL1 locus, has previously been reported to be genome-wide significant, both conferring risk of PBC23 and protection against MS.2 It has been shown that for ADs the most associated variant at a given locus frequently differs between the diseases and, even when shared, the same allele often has opposite effect.13 We excluded the variants with discordant effect from further analysis. The gene discussed is MMEL1; the disease is myeloid sarcoma.