DNMT3A and colorectal adenocarcinoma: Intriguingly, ovarian cancer is specifically associated with PPM1D mutations, which is supported by previous report.3 We also observe associations of head and neck squamous cell carcinoma with PPM1D, colorectal adenocarcinoma, and glioblastoma with TET2. Interestingly, cutaneous melanoma is associated with ASXL1 mosaic mutations as ASXL1 has protein-interaction with BAP1, a well-established risk factor for melanoma.12 Lung cancer shows a burden of mosaic mutations that is distributed across several genes with DNMT3A being the most statistically significant.