In 5 of the 76 diseases, our goal was the over-expression of a paralog; the concept of treating a genetic disease by modulating expression of a gene that functionally compensates (at least partly) the mutation gene is a well-known but comparatively unused therapeutic approach exemplified by SMN2 induction in spinal muscular atrophy (7). This evidence concerns the gene SMN2 and proximal spinal muscular atrophy.