The correlation between the CD19 DNase1-seq profile or CD19 H3K4me1 and regional mutation frequency was higher for CLL than MBL for chromosome 2 (Fig. 2c) and other chromosomes (Supplementary Fig. 3a), but this finding might be due to the different number of samples between MBL and CLL, as the correlation score for MBL for all of the chromosome was highly similar to the correlation scores for CLL (−0.76 vs. −0.75 for DNase1-seq, −0.74 vs.−0.75 for H3K4me1) after sample-number matching. Here, CD19 is linked to B-cell chronic lymphocytic leukemia.