Notably, the epigenetic modifiers TET1 (chromosome 10) and DNMT1/3B (chromosomes 19 and 20) were haploid and polyploid in tumour respectively, which suggests a connection between the observed hypermethylation (DNMT polyploidy) and 5hmC loss (diminished TET function) in the tumour. Here, TET1 is linked to neoplasm.