The NXN gene is expressed in murine heart and there is evidence that loss of the NXN gene is associated with CHD in mice.27 In humans, the gene is expressed in human heart and has a haploinsufficiency prediction score of 37.4%,28 as well as RVIS (Residual Variation Intolerance Score)29 percentile of 11.77% (i.e., the top 11.77% most intolerant of human genes to variation). This evidence concerns the gene NXN and coronary artery disorder.