Isolated case reports indicate a link between CHD and large deletions in this region at the resolution of the chromosome band, including two from Taiwan and Japan with ToF30 and PAVSD,31 respectively, that overlap NXN. This suggests that a critical region for CHD may be located in the region of the NXN gene (Figure 3), in addition to the more proximal MDS region (Figure 3). Here, NXN is linked to coronary artery disorder.