TP53 and melanoma: However, in this test, TP53 was part of a larger gene panel, which revealed a hemizygous deletion of all three p16INK4A exons of CDKN2A. Given the absence of a personal or family history of melanoma, which might be expected in individuals with CDKN2A (specifically p16INK4A) mutations, we performed germline whole-genome sequencing (WGS) to further elucidate the basis for this patient’s disease.