SPMIP7 and Crohn disease: SNPs in C7orf72, including the same SNP we have identified as being associated with AS (rs1456896), have been associated with Crohn’s disease.18FAM118A variants have previously been associated with bone mineral density.22 Strong linkage disequilibrium exists between the bone mineral density-associated SNP (rs136564) and the AS-associated SNP, rs6007594 (r2=0.03, Dʹ=0.92).