A recent report by Puissant et al.,26 describe that the product of DDIT4 could be cleaved by caspase 3 modifying its cellular function exerting anti-proliferative activities.26 TCGA data show that dysregulation of this gene in 4% of breast tumours, mainly overexpression (altered in 12% of tumours basal subtype). This evidence concerns the gene CASP3 and breast neoplasm.