POLR1C and breast cancer: The POLR1C gene (30 kDa), encodes a subunit of the RNA polymerase enzymes I and III, responsible for RNA synthesis.27 The mutation in this gene causes Treacher Collins syndrome that affects the development of bones and facial tissues.28POLR1C gene is recurrently amplified and overexpressed in gastric cancer.29 TCGA data indicate that 11% of breast cancer cases have dysregulations in this gene (overexpression and downregulation).