The CD8 antigen is a cell-surface glycoprotein found on most cytotoxic T lymphocytes that mediates the killing of cancer cells.32 At the same time, the presence of the CD8+ lymphocytes has a positive effect on survival.31 This coincides with the fact that patients with HPV+ profiles have a six times higher probability to respond to conventional (chemo-) radiotherapy compared with those with HPV− HNSC profiles.33 Here, CD8A is linked to cancer.