Apparently, in HPV16+ HNSC tumours the ATM–E2F1 signalling pathway is altered so that elevated expression of CDKN2B-AS no longer controls transcriptional silencing of CDKN2A–CDKN2B locus, but in contrary is associated with elevated expression of these tumour-suppressor genes. This evidence concerns the gene CDKN2B and neoplasm.