Our hypothesis that an informative gene set has higher chances to be enriched in a typical transcriptomic data analysis, is tested here (see Methods section for the procedure) in four typical scenarios: (i) colorectal cancer KRAS mutated vs. wild type;10 (ii) colon cancer metastatic vs. primary (same samples profiled with two platforms: RNA–seq and microarrays);11 (iii) tumor vs. normal in four tissues (lung,12 gastric,13 colon,14 cervix15) and (iv) breast cancer late vs. early stage (from two independent data sources: TCGA and METABRIC16). Here, KRAS is linked to breast carcinoma.