KRAS and cancer: Indeed KRAS mutation has already been shown to induce mitochondrial oxidative stress, responsible for the so-called Warburg effect, a metabolic alteration fundamental for cancer cell proliferation.26–28 In CRC, KRAS mutation also causes an alteration of the transcriptional response and amino acid metabolism machineries, two processes involved in cancer cell proliferation and maintenance.29,30 This effect is captured in our analysis by the upregulation of the mRNA translation/protein metabolism areas of InfoSigMap.