PLAUR and neoplasm: This study reported that urokinase plasminogen activator receptor (uPAR) downregulation induces tumor dormancyin vivo through the inhibition of the physical interaction between uPA/uPAR proteins with the α5β1 integrin, resulting in lower adhesion of the cells to fibronectin and lower mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway activation19.