Barkanet al. found that the engagement of ITGB1 and downstream signaling through the activation of FAK, Src, ERK1/2, and myosin light-chain kinase (MLCK) was responsible for the dormant-to-proliferative switch of D2.0R mammary tumor cells bothin vitro andin vivo27,28. The gene discussed is MYLK; the disease is breast cancer.