We also observed an inverse correlation between DR5 and Ki67 where grade 0 HCC exhibit high DR5/low Ki67 and high-grade HCC exhibit low DR5/high Ki67 indicating that strategies to increase DR5 expression using Pro-Apoptotic Receptor Agonists (PARAs) might be useful in targeting HCC. This evidence concerns the gene MKI67 and hepatocellular carcinoma.