THBD and respiratory system disorder: Genes responsible for nonspecific defense mechanisms against all respiratory disease pathogens11 such as those encoding mucins, pattern recognition receptors (PPRs), host defense peptides (such as defensins, lactotransferrin and secretory leukoprotease inhibitor), and matrix metallopeptidase family members were consistently found to be DE across all challenge groups and tissues as were genes with reactive oxygen and wound healing (coagulation factors, THBD and VWF) functions.