NR1H4 and central nervous system cancer: Seven pathways that were significantly implicated included nuclear receptor activations (“LXR/RXR activation” and “FXR/RXR activations”), “Atherosclerosis Signaling”, lipid transport (“Clathirin mediated Endocytosis Signaling”), immune cell responses (“IL-12 Signaling and Production in Macrophages”, “Production of Nitric Oxide and Reactive Oxygen Species in Macrophages) and “Glioma Signaling” (P-value 1.10 × 10−5–0.019, Supplementary Table VI and Supplementary Figure III).