LPL and coronary artery disorder: Mutations in other genes that affect TG levels are also associated with CAD, for example, a common gain-of-function LPL variant, S447X, is associated with low TG level and lower MI risk42 and in another study, the aggregate of rare mutations in the gene encoding apolipoprotein C3 (APOC3) was associated with lower TG levels, and contribute to a reduced risk of CAD43.