We further showed that the rs2075291 association was independent of the reported GWAS index SNP, rs964184, at the APOA5 locus3 as well as −1131C > T (rs662799) promoter polymorphism and a 3′ untranslated region polymorphism (rs2266788), which are strongly associated with CAD risk30,31. Here, APOA5 is linked to coronary artery disorder.