ST2L-associated regulation of osteogenic differentiation has been previously shown in osteosarcoma cells14 and analysis of the skeletal phenotype has indicated enhanced bone resorption in ST2 deficient mice highlighting a negative influence of IL-33/ST2 signaling pathway on the osteoclastogenesis that was corroborated by in vitro studies as well13. Here, IL33 is linked to osteosarcoma.