Finally, to analyse the potential impact of tumor microenvironment derived ANXA1 on the regulation of tumour growth in vivo, 4T1 murine breast cancer cells which harbor a luciferase promoter (4T1-12B) were injected into the 4th left mammary gland of female BALB/c WT and ANXA1−/− mice. The gene discussed is ANXA1; the disease is breast carcinoma.