AK6 and hereditary disease: In this context, it is worth mentioning that haplo-insufficiency of Rps14 in human cells has been linked to the genetic disorder 5q-syndrome, a sub-type of the myelodysplastic syndrome characterized by a defect in erythroid differentiation with onset of acute myeloid leukemia53, and that human Fap7 (hCINAP) is highly expressed in cancer cells and promotes malignacy by selectively modulating the cancer-associated translatome54.