EIF4EBP1 and cancer: Our discovery of Snail as an important modulator of 4E-BP1 expression and cancer cell sensitivity to mTORkis suggests that the limited preclinical and clinical efficacies of mTOR inhibition in breast, colorectal and other cancers52 may be attributed, in part, to the frequent genetic gains by Snail associated with decreased expression of 4E-BP1.