As compared with cancer cells with low Snail/high 4E-BP1 expression (MCF7, T47D, ZR75-1, and DLD-1, Fig. 1a), cancer cells expressing high Snail/low 4E-BP1 (MDA-231, MDA-157, SUM149, and HCT116, Fig. 1a) were significantly less sensitive to both AZD8055 and INK128, with a five to seven fold increase in half-maximal growth inhibitory concentration values (Fig. 5a, b). This evidence concerns the gene SNAI1 and cancer.