ERBB2 and cancer: The aims of this work were 2-fold: first, to explore alternative ways to coexpress the scFv to HER2 for cancer retargeting and the GCN4 peptide for in vitro cultivation in the Vero-GCN4R cells; second, to define novel, less disadvantageous detargeting strategies so as to optimize the cultivation of retargeted oncolytic HSVs in the noncancer cells.