To gain more quantitative insight into how NMDAR current in these mPanNET tumour cells is influenced by, and influences membrane potential in physiological magnesium, we constructed a computational model incorporating the main voltage-gated conductances (CaV1/CaV2, KV2.1) which drive spike generation in normal mouse pancreatic β cells from which mPanNETs derive [14], with magnitudes determined by our voltage-clamp measurements. Here, KCNB1 is linked to neoplasm.