For example, it has been shown using this approach that the pyrrole, Compound 1, primarily targets PKG during events such as rounding up of P. falciparum gametocytes, merozoite egress and sporozoite gliding/hepatocyte infection; however, the compound has alternative primary targets during exflagellation [18] and early-blood-stage development [17]. The gene discussed is PRKG1; the disease is infection.